中文名鹽 酸奧替尼啶
英文名N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium)dichloride
別名奧替尼啶雜質(zhì)
鹽 酸奧替尼啶
奧替尼啶鹽 酸鹽
奧克太啶鹽 酸鹽
奧替尼定鹽 酸鹽
奧替尼啶,奧克太啶
奧替尼啶 二鹽 酸鹽
奧替尼啶 奧克太啶(雙鹽 酸鹽)
英文別名Octenidine HCl
Octenidine hydrochloride
ocenidine dihydrochloride
OCTENIDINE DIHYDROCHLORIDE
N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM)dichloride
N,N'-(decane-1,10-diyldipyridin-1-yl-4-ylidene)dioctan-1-aminedihydrochloride
N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium)dichloride
N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMineHydrochloride
N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine)dihydrochloride
CAS70775-75-6
EINECS274-861-8化學(xué)式C36H64Cl2N4
分子量623.82616InChIInChI=1/C36H62N4.2ClH/c1-3-5-7-9-15-19-27-37-35-23-31-39(32-24-35)29-21-17-13-11-12-14-18-22-30-40-33-25-36(26-34-40)38-28-20-16-10-8-6-4-2;;/h23-26,31-34H,3-22,27-30H2,1-2H3;2*1HInChIKeySMGTYJXN密度1.046[at 20℃]熔點(diǎn)215-217℃沸點(diǎn)609.3°C at 760 mmHg閃點(diǎn)322.3°C水溶性14.2g/L at 20℃蒸汽壓0Pa at 25℃溶解度溶于二甲亞 砜和甲醇。存儲(chǔ)條件Keep in dark place,Inert atmosphere,Room temperature穩(wěn)定性吸濕性外觀固體顏色White to Off-WhiteMerck14,6754體外研究Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes agreater than 99% reduction of tested microbial population within 15min. Staphylococcus epidermidis is the most susceptible of the testorganisms, and E. coli and C. albicans are the leastsusceptible.體內(nèi)研究The antimicrobial activity of octenidine hydrochloride (OCT) ismaintained when applied to the skin of the hands and feet ofcynomolgus monkeys. Aqueous octenidine, at a concentration of 0.2to 1.6% reduces resident microflora populations from 90 to 99.98%.A significant reduction in plaque score is observed on the buccaltooth surfaces after daily topical application of 1% solutions ofoctenidine and chlorhexidine for 7 d; octenidine is more effectivethan chlorhexidine.上游原料4-(辛基氨基) 1,10-二氯癸烷 4-