中文名(S)-10-羥基喜樹堿
英文名(s)-10-hydroxycamptothecin
別名羥基喜樹堿
10-羥基喜樹堿
(S)-10-羥基喜樹堿
(20S)-10-羥基喜樹堿
10-(±)羥基喜樹堿標(biāo)準(zhǔn)品
英文別名160177
10-HCPT
Hydroxycamptothecin
Hydroxy Camptothecine
Hydroxy camptothecine
10-Hydroxycamp-totecin
10-hydroxycamptothecin
10hydroxy camptothecin
10-hydroxy camptothecin
7ETHYHYDROXYCAMPTOTHECIN
7-ethy hydroxycamptothecin
(s)-10-hydroxycamptothecin
10-HYDROXYCAMPTOTHECIN ACETATE
7-ETHYL-10-HYDROXY CAMPTHOTECIN
77-Ethyl-10-hydroxy campthotecin
10-HYDROXYCAMPTOTHECIN ACETATE SALT
(20S)- 7-Ethyl-10-Hydroxycamptothecin
CAS64439-81-2
19685-09-7
EINECS613-598-9化學(xué)式C20H16N2O5
分子量364.35InChIInChI=1/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1InChIKeyLCZZWLIDINBPRC-F密度1.60熔點230-237°C沸點820.7±65.0 °C(Predicted)閃點450.1°C蒸汽壓1.67E-28mmHg at 25°C溶解度不溶于水，溶于稀堿溶液，難溶于甲醇、氯仿、，微溶于甲醇-氯仿混合溶劑。折射率1.776酸度系數(shù)8.93±0.40(Predicted)存儲條件Keep in dark place,Inert atmosphere,Store in freezer, under-20°C外觀淡黃色粉末物化性質(zhì)Appearance: Yellow crystal
melting point: 268 ℃~270 ℃
MDL號MFCD02093100體外研究(±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor oftopo I. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedlyinhibits the proliferation of Colo 205 cells in a dose-dependentmanner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cellsin the G2 phase of the cell cycle and triggers apoptosis through acaspase-3-dependent pathway. (±)-10-Hydroxycamptothecin (HPT,0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation andcondensed chromosomes and induces apoptosis of human urinarybladder cancer cell line (T24).體內(nèi)研究(±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.)significantly suppresss tumor growth in mouse xenografts.(±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4days) causes no obvious acute toxicity in nude mice.危險品標(biāo)志Xi - 刺激性物品
T - 有毒物品
風(fēng)險術(shù)語R36/37/38 - 刺激眼睛、呼吸系統(tǒng)和皮膚。
R25 - 吞食有毒。
安全術(shù)語S26 - 不慎與眼睛接觸后，請立即用大量清水沖洗并征求醫(yī)生意見。
S36 - 穿戴適當(dāng)?shù)姆雷o服。
S45 - 若發(fā)生事故或感不適，立即就醫(yī)(可能的話，出示其標(biāo)簽)。
危險品運輸編號UN 2811 6.1 / PGIIIWGK Germany3RTECSU參考資料
查看更多
1. 邢志華, 方桂珍. 離子交聯(lián)法制備葉酸-殼聚糖微球工藝研究[J]. 黑龍江醫(yī)藥, 2011, 24(6):915-917.2.邢志華, 方桂珍, 蘇玲,等. 羥基喜樹堿葉酸-殼聚糖納米粒的制備及其性能研究[J]. 功能材料, 201...