中文名大環(huán)哌喃
英文名Tacrolimus
別名大環(huán)哌喃
他克莫斯
泰克利馬
他克莫司
他可莫司
他克莫司標(biāo)準(zhǔn)品
他克莫司FK-506
他可莫司(FK506)
英文別名FK-506
L679934
Protopic
Tacrolimus
Tacarolimus
,19s*,26ar*))-
FujimycinProzraf
16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1
3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12,
(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*
(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
CAS104987-11-3
EINECS1308068-626-2化學(xué)式C44H69 N O12
分子量804.02InChIInChI=1/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19-,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1InChIKeyZNUXCKSA-N密度1.19±0.1 g/cm3(Predicted)熔點(diǎn)113-115°C沸點(diǎn)871.7±75.0 °C(Predicted)比旋光度-84.4 (c, 1.02 in CHCl3)閃點(diǎn)2℃水溶性Freely soluble in DMSO or ethanol. Poorly soluble in water.Solublein dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethylacetate, ether, methanol and dimethyl formamide.蒸汽壓1.73E-35mmHg at 25°C溶解度DMSO: >3mg/mL折射率1.549酸度系數(shù)9.97±0.70(Predicted)存儲(chǔ)條件Sealed in dry,Store in freezer, under -20°C穩(wěn)定性Stable for 2 years from date of purchase as supplied. Solutions inDMSO or ethanol may be stored at -20°C for up to 2 months.外觀solid顏色white物化性質(zhì)單水合物：C44H69NO12?H2O。從乙腈中得無(wú)色棱狀結(jié)晶，熔點(diǎn)127～129℃。[α]D20-84.4°(C=1.02，氯仿)。溶于甲醇、乙醇、丙酮、乙酸乙酯、氯仿或yimi，難溶于己烷或石油醚，不溶于水。急性毒性LD50小鼠(mg／kg)：＞200腹腔注射。急性毒性LD50雄、雌大鼠(mg/kg)：57．0，23.6靜脈注射；134，194口服。
