Products for Solid Phase Peptide Synthesis/Combinatorial Chemistry
Tulsion?CMB Polymers提供固相合成肽生物科技
特麥仕制造特殊等級的杜笙 Polymers 用于生物科技固相法的肽合成步驟使用。
Thermax makes special Tulsion? Polymers having applications in the biotechnology area specially for solid phase peptide synthesis .
杜 笙 CMB 高分子樹脂具有能應用于肽的合成的甲基氯官能基.以此種樹脂用來合成肽的技術是由Merrified 于1963年發(fā)明。肽的化學鍵的行成是由此種樹脂的官能基與氨基酸鍵結合而來。在去除保護的官能基之后，一個個新的氨基酸分子便產(chǎn)生來增加其肽的化學鍵。 此肽的化學鍵的增長是一步一步合成而來的。在每個步驟中過濾掉多余的反應劑。在Zui后的合成步驟是去除所有的保護官能基并將肽從此樹脂中分離出來。此種樹脂 的特性可以根據(jù)客戶需要制造，用來適用不同的合成步驟。它們根據(jù)嚴格的質量標準在非常認真的控制條件下制造。

Tulsion? CMB polymers have chloromethyl functionality and are used for peptide synthesis.Use of such polymers for peptide synthesis was initiated by Merrifield in 1963. The formation of peptide bond starts with reaction of a protected amino acid molecule with chloromethyl group on the surface of the polystyrene polymer. After removal of the protecting group, a new amino acid molecule is reacted to elongate the peptide chain. The elongation is continued with stepwise addition. Excess reagents and byproducts are removed by filtration at each step. The final step in the synthesis involves freeing up of the protecting group as well as liberating the peptidefrom the polymer. Properties of the polymers can be tailor-made to suit individual application needs.

They are made under very carefully controlled conditions using strictest standards.

Tulsion? CB polymers:

所有高分子合成的基礎是聚合物基質。Tulsion? CB 100 / 200
是Zui常用的型號。固相有機合成的Zui重要考慮因素是樹脂的顆粒大小及膨脹因素。而膨脹因素是由樹脂本身的鍵結程度 ,水合以及物質的特性有關。
Tulsion?CB 100 / 200 本身特質具有很好的疏水特性并且在非極性的溶劑中膨脹。他們用于固相的有機合成與DVB 產(chǎn)生交叉鍵結而具有穩(wěn)定的機械結構.

The foundation of all polymeric synthesis is the polymeric matrix. Tulsion?CB 100 / 200 is commonly used resin. The most important characteristics considering solid phase organic synthesis are the swelling factor and the bead size of the resin. The swelling characteristics areaffected by the factors such as degree of crosslinking, hydrophobisity of substrate and nature ofthe matrix.

Tulsion? CB 100 / 200 itself is very hydrophobic in nature and swells in a non-polar solvent. It is used in solid phase organic chemistry is crosslinked with DVB to give mechanically stable matrix in presence of swelling solvents.

Tulsion?CB 100 / 200 resins are used in variety of reactions to give Chloromethyl resins or Merrifield resins (Tulsion?CMB), Wang resins chlorotrytil resins and other resins used in solidphase peptide synthesis.

技術資料

Technical Characteristics -

Tulsion?

CMB 100

CMB 200

CB 100

CB 200

結構

Matrix Structure

交聯(lián)聚苯乙烯

Crosslinked Polystyrene

交聯(lián)聚苯乙烯

Crosslinked Polystyrene

交聯(lián)聚苯乙烯

Crosslinked Polystyrene

交叉鍵結高分子Crosslinked Polystyrene

官能基

Functional Group

氯甲基

Chloromethyl

FB(Free Base) . 自由基

苯氛

Plane Polystyrene

苯氛

Plane Polystyrene

顆粒大小

Particle Size (ASTM)

100 – 200

200 – 400

100 – 400

200 - 400

總氯含量
Total Chloride Content

(meq/dry gm)

0.8 – 0.4

4 – 0.4

-

-

Zui大含水量 , %Moisture Content Max

1

1

1

1

溶解率

Solubility

不溶于所有的溶劑

Insoluble in all solvent

不溶于所有的溶劑

Insoluble in all solvent

不溶于所有的溶劑

Insoluble in all solvent

不溶于所有的溶劑

Insoluble in all solvent

特性

Features

顆粒狀

Free flowing spherical beads

顆粒狀

Free flowing spherical beads

顆粒狀

Free flowing spherical beads

顆粒狀

Free flowing spherical beads